Kre-Alkalyn: A Scientific Creatine Review

Kre-Alkalyn has been touted as a revolutionary new form of Creatine that is more readily absorbed by the body due to its stable high PH levels, stopping the Creatine(good stuff) from turning into Creatinine(useless stuff). We take a look at whether the scientific evidence backs up these claims.

Like me, I am sure many of you have noticed an increase in the amount of fitness related supplements over the past few years. From testosterone boosters and pro-hormones to branch-chain amino acids and l-glutamine, there are simply hundreds of products that claim to increase performance and/or recovery.

In this article we will analyse the effectiveness of a product which claims to have improved the effectiveness of an already well known and researched performance supplement, namely, creatine.

Generally, the most commonly used form of creatine as a supplement is creatine monohydrate. It is scientifically accepted that creatine monohydrate, taken at appropriate doses, increases physical performance to a certain degree. I will not go into the details of how creatine monohydrate increases performance as it is widely accepted by the scientific community that it does.

What I will investigate more, is the claimed effects of ‘Kre-Alkalyn’, a PH balanced form of creatine.

Basically, what EFX, the makers of Kre-Alkalyn are stating is that:

“The main problem with all existing creatine supplementation is the ability to deliver creatine in a usable form by the human body. Research has shown that known creatine delivery systems actually have the human body ingesting creatinine, a poison and toxic by-product. It is believed that the main reason for complaints resulting from creatine consumption, namely, stomach cramps, edema, bloodedness and dehydration, is caused by the body’s defence to this toxic compound.

The known oral creatine supplements are dissolved in acidic solutions having a pH range of from 3-6. Research has shown that at these pH levels, the rate of conversion of creatine to creatinine is almost instantaneous.

From the above, it may be ascertained that a need exists for a method of enhancing the delivery of usable creatine to humans without substantial creatinine being formed. Further, a need exists for an oral creatine supplement that is in the form of a powder, capsule, tablet or liquid that is stable when mixed with water or taken premixed or in pill form. (Golini; Jeffrey M 2001, Oral creatine supplement and method for making same US Patent 6,399,661).”

In a nutshell, EFX are stating that because Kre-Alkalyn has a PH between 7-14, it will not convert as quickly to creatinine when ingested by humans and will therefore be more effective as a supplement over creatine monohydrate (which is claimed by EFX to have a PH of between 3-6 when ingested, and therefore convert to creatinine instantaneously).

I am a self-confessed scientific lay-person, but I do have good investigative skills, which lead me to my next point.

What EFX are claiming is completely and utterly false. Why you ask?

It is simple really, the claimed superior effects of Kre-Alkalyn against creatine monohydrate were studied and were proven to be false (Jagim et al).

I have included the summary below for you convenience (FYI ‘CrM is Creatine Monohydrate; ‘KA is Kre-Alkalyn):

“In a double-blind manner, 36 resistance trained participants (20.2±2 yrs., 181±7 cm, 82±12 kg, 14.7±5 % body fat) were randomly assigned to supplement their diet with CrM (Creapure®, AlzChem AG, Germany) for 28-days (20 g/d for 7-d, 5 g/d for 21-d), an equivalent amount of KA as a high dose supplement (KA-H), or the manufacturer’s recommended dose of KA (1.5 g/d for 28-d, KA-L). Participants were asked to maintain their current training programs and record all workouts.

Muscle biopsies from the vastus lateralis, fasting blood samples, body weight, DEXA determined body composition, 1RM bench press and leg press, and Wingate Anaerobic Capacity (WAC) tests were performed at 0, 7, and 28-days. Data were analysed by MANOVA with repeated measures and are presented as mean ± SD changes from baseline after 7 and 28-d, respectively….Neither manufacturers recommended doses or equivalent loading doses of KA promoted greater changes in muscle creatine content, body composition, strength, or anaerobic capacity than CrM. These findings do not support claims that KA is a more efficacious form of creatine.”(Jagim et al)

I have personally tried Kre-Alkalyn, over a period of about 2 months during a 4 day per week weight training, and 2 day per week cardio training routine. I took 2 of the 1.5g capsules per day. In my opinion, it did nothing. I have tried creatine monohydrate previously and I can say with certainty that, Kre-Alkalyn does not compare in the slightest in terms of performance.

What is of more interest to me is that if you do a simple Google search with ‘Kre-Alkalyn’ reviews, most people give it excellent ratings, many say it dramatically improves performance, endurance and strength, even more so than creatine monohydrate.

I again admit to being a creature of science, I rarely believe something that is not scientifically proven.

And I certainly believe in the effects of a placebo.

If all these people believe that Kre-Alkalyn works better, then maybe it does. It’s up to you what you want to believe. I am simply an investigator, and I am putting the facts to you, so you can make an informed decision.

If you are looking for a supplement to increase performance, I would recommend a creatine that has been scientifically proven to enhance performance.

If you are going to invest in a good quality creatine that has a scientific backing (I.e. monohydrate), I would recommend creapure creatine.

Creapure creatine is monohydrate, exceptionally high in quality (German made) and will give you all the benefits of creatine, without the over-engineered, un-warranted improvements made by EFX through Kre-Alkalyn.

Kre-Alkalyn Rating:

  • Claims advantages over creatine monohydrate which have been proven to be false.
  • Using the recommended dosage does not provide increased performance as compared to monohydrate, it is actually remarkably less.
  • Great product if you believe in the power of a placebo.

Article by CS.

Creapure creatine is my recommended source of creatine. Provided by Amazon.

Golini; Jeffrey M 2001, Oral creatine supplement and method for making same US Patent 6,399,661.
Jagim et al.: Kre-Alkalyn® supplementation does not promote greater changes in muscle creatine content, body composition, or training adaptations in comparison to creatine monohydrate. Journal of the International Society of Sports Nutrition 2012 9(Suppl 1):P11.

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